TL;DR: Aetna, a CVS Health company, modified CPB 0171 governing extremity MRI coverage, effective September 26, 2025. Billing teams submitting CPT codes 73218–73223 (upper extremity) and 73718–73723 (lower extremity) need to verify their documentation matches updated medical necessity criteria before claims go out.
Quick-Reference Table
| Field | Detail |
|---|---|
| Payer | Aetna, a CVS Health company |
| Policy | Magnetic Resonance Imaging (MRI) of the Extremities |
| Policy Code | CPB 0171 |
| Change Type | Modified |
| Effective Date | September 26, 2025 |
| Impact Level | High |
| Specialties Affected | Orthopedics, Radiology, Podiatry, Oncology, Vascular Surgery |
| Key Action | Audit documentation for knee MRI orders to confirm they meet at least one of five listed medical necessity criteria before billing CPT 73721–73723 |
Aetna Extremity MRI Coverage Criteria and Medical Necessity Requirements 2025
The Aetna extremity MRI coverage policy under CPB 0171 Aetna system covers a defined set of clinical indications. "Medically necessary" is not a loose standard here — Aetna lists five specific knee MRI criteria, and your documentation needs to match at least one of them. Vague orders citing "knee pain" won't hold up on review.
Here's what qualifies for knee MRI (CPT 73721, 73722, 73723) under this coverage policy:
Tumor detection, staging, or post-treatment evaluation. ICD-10 codes like C49.20–C49.22 (malignant connective tissue, lower limb) and D21.20–D21.22 (benign connective tissue, lower limb) anchor this indication. The documentation needs to reflect an active oncologic workup or follow-up — not just a history of cancer.
Persistent knee pain, swelling, or instability. This splits into two sub-tracks. For non-injury pain, the patient must have failed at least three weeks of conservative therapy. Aetna defines conservative therapy explicitly: rest, ice, compression, elevation, NSAIDs, crutches, and range-of-motion exercises. All of them in combination — not just ibuprofen for a week.
For injury-related pain, the bar is different. Multi-view x-rays must have ruled out a fracture or loose body, and the clinical picture must remain uncertain after that. Both conditions have to be true. Document the x-ray results and spell out why the clinical picture is still unclear.
True locking of the knee. This indication comes with a clinical definition you should paste into your documentation template. True locking is more than a momentary locking with the knee flexed. It's not the "catching" sensation many patients describe in extension. If the chart says "catching" and not "locking," Aetna can deny the claim. Your ordering providers need to know this distinction.
Suspected osteomyelitis or osteonecrosis. For bone infection, the clinical suspicion itself triggers coverage. For osteochondritis dissecans or osteonecrosis, there's an added requirement: the clinical picture — including x-rays — must not be confirmatory. If x-rays already establish the diagnosis, the MRI doesn't meet medical necessity under this policy.
Beyond the knee, CPB 0171 also covers MRI for several other indications. MRI for CLOVES syndrome diagnosis is covered. MRI for osteomyelitis in the foot is covered. MRI for Morton neuroma (ICD-10 G57.60–G57.63) is covered for pre-operative planning — but only after a symptomatic neuroma is identified on plain x-ray and non-surgical treatments have failed. Those treatments include metatarsal support, padded shoe inserts, and steroid or local anesthetic injections (CPT 64450). All three need to have been tried and failed before the MRI is billable.
Whole-body MRI for malignancy screening is covered specifically for patients with Li-Fraumeni syndrome. This is a narrow indication — don't apply it broadly to other hereditary cancer syndromes.
MRI-lymphangiography for peripheral lymphedema is covered when lymphedema is the suspected cause of peripheral edema and initial noninvasive studies — specifically ultrasound — have come back negative. The sequencing matters. Ultrasound first, MRI-lymphangiography second.
If you're unsure how these criteria map to your patient mix, loop in your compliance officer before September 26, 2025.
Aetna Extremity MRI Exclusions and Non-Covered Indications
CPT 70554 and 70555 — functional MRI of the brain — are explicitly not covered for indications listed in CPB 0171. Those codes cover brain functional MRI, including neurofunctional testing. They don't belong in an extremity MRI claim, and submitting them under this policy will result in a claim denial.
The policy also excludes CPT 73721–73723 for fitting of prosthetics. The full code description in the policy notes this exclusion directly. If you're billing joint MRI of the lower extremity in the context of prosthetic fitting, that's not a covered indication under CPB 0171.
Coverage Indications at a Glance
| Indication | Status | Relevant Codes | Notes |
|---|---|---|---|
| Knee MRI — tumor detection, staging, post-treatment | Covered | 73721–73723; C49.20–C49.22, C76.50–C76.52, D21.20–D21.22, D48.0 | Document oncologic workup or active follow-up |
| Knee MRI — non-injury pain/swelling, no response to conservative therapy | Covered | 73721–73723 | Requires ≥3 weeks of conservative therapy (rest, ice, compression, elevation, NSAIDs, crutches, ROM) |
| Knee MRI — injury-related pain, x-rays negative, clinical picture uncertain | Covered | 73721–73723 | Multi-view x-rays must rule out fracture or loose body; clinical uncertainty must be documented |
| Knee MRI — true locking of the knee (meniscus tear or loose body) | Covered | 73721–73723 | Must meet definition of "true locking" — not momentary catching |
| Knee MRI — suspected osteomyelitis | Covered | 73721–73723 | Clinical suspicion sufficient; document clearly |
| Knee MRI — suspected osteochondritis dissecans or osteonecrosis, x-rays not confirmatory | Covered | 73721–73723 | X-rays must be inconclusive |
| MRI — CLOVES syndrome diagnosis | Covered | 73218–73223, 73718–73723 | — |
| MRI — osteomyelitis of the foot | Covered | 73718–73720 | — |
| MRI — Morton neuroma, pre-operative planning | Covered | 73718–73720; G57.60–G57.63 | Neuroma on plain x-ray + failed metatarsal support, padded inserts, and steroid/anesthetic injections |
| Whole-body MRI — malignancy screening in Li-Fraumeni syndrome | Covered | 73218–73223, 73718–73723 | Li-Fraumeni syndrome diagnosis required |
| MRI-lymphangiography — peripheral lymphedema evaluation | Covered | 73218–73223, 73718–73723 | Ultrasound must be negative first |
| Functional MRI of the brain (CPT 70554, 70555) | Not Covered | 70554, 70555 | Explicitly excluded under CPB 0171 |
| Lower extremity joint MRI for prosthetic fitting | Not Covered | 73721–73723 | Excluded per code description in policy |
Aetna Extremity MRI Billing Guidelines and Action Items 2025
These are direct steps your billing and clinical teams should take before the September 26, 2025 effective date.
| # | Action Item |
|---|---|
| 1 | Audit your knee MRI order templates. Pull every template your ordering providers use for CPT 73721, 73722, and 73723. Confirm each one captures the specific medical necessity criterion being met — not just a symptom description. "Knee pain" is not a qualifying criterion. "Knee pain not responding to three weeks of NSAIDs, rest, ice, compression, elevation, and ROM exercises" is. |
| 2 | Add the conservative therapy checklist to your pre-auth documentation. Aetna's definition of conservative therapy is explicit. If you're billing for non-injury knee pain (the most common scenario), your prior authorization request needs to show all components of that regimen were used and failed. Missing one element gives Aetna grounds to deny. |
| 3 | Train providers on the true locking distinction. Print out Aetna's definition and put it in the ordering workflow. If a provider documents "catching" when they mean "locking," your MRI billing for a torn meniscus indication is at risk. This is a fixable documentation problem — but only if providers know it exists. |
| 4 | Update your x-ray sequencing documentation for injury cases and osteochondritis/osteonecrosis. For injury-related knee MRI and suspected osteonecrosis, multi-view x-rays must precede the MRI order and be documented as negative or inconclusive. If x-rays aren't in the chart before the MRI is ordered, you're looking at a potential claim denial. Make the radiology sequence part of the order workflow. |
| 5 | Check Morton neuroma claims for full non-surgical treatment documentation. For CPT 73718–73720 billed with G57.60–G57.63, all three non-surgical treatments — metatarsal support (HCPCS L3050), padded shoe inserts (HCPCS L3030), and steroid/anesthetic injections (CPT 64450) — must be documented as tried and failed. Missing any one of them is a denial waiting to happen. |
| 6 | Verify prior authorization requirements for your specific plan. CPB 0171 sets medical necessity criteria, but individual Aetna plan designs may layer on prior authorization requirements for CPT 73218–73223 and 73718–73723. Check your contract and plan-level requirements. Don't assume medical necessity documentation alone clears the claim. |
| 7 | Flag Li-Fraumeni syndrome and CLOVES syndrome cases for specialty review. These are rare indications with specific diagnosis requirements. If your team bills whole-body MRI for Li-Fraumeni screening or MRI for CLOVES diagnosis, confirm the underlying diagnosis is documented and coded correctly before submission. |
| Previous Version | Current Version |
|---|---|
| Coverage is considered experimental and investigational for all indications | Coverage is considered medically necessary when specific criteria are met |
| Prior authorization is not required | Prior authorization is required for initial treatment |
| Documentation must include clinical history | Documentation must include clinical history |
| Re-review every 24 months | Re-review every 12 months with updated clinical documentation |
CPT, HCPCS, and ICD-10 Codes for Extremity MRI Under CPB 0171
Covered CPT Codes (When Selection Criteria Are Met)
| Code | Type | Description |
|---|---|---|
| 73218 | CPT | Magnetic resonance imaging, upper extremity, without contrast |
| 73219 | CPT | Magnetic resonance imaging, upper extremity, with contrast |
| 73220 | CPT | Magnetic resonance imaging, upper extremity, without contrast, followed by with contrast |
| 73221 | CPT | Magnetic resonance imaging, any joint of upper extremity, without contrast |
| 73222 | CPT | Magnetic resonance imaging, any joint of upper extremity, with contrast |
| 73223 | CPT | Magnetic resonance imaging, any joint of upper extremity, without contrast, followed by with contrast |
| 73718 | CPT | Magnetic resonance imaging, lower extremity, without contrast |
| 73719 | CPT | Magnetic resonance imaging, lower extremity, with contrast |
| 73720 | CPT | Magnetic resonance imaging, lower extremity, without contrast, followed by with contrast |
| 73721 | CPT | Magnetic resonance imaging, any joint of lower extremity, without contrast |
| 73722 | CPT | Magnetic resonance imaging, any joint of lower extremity, with contrast |
| 73723 | CPT | Magnetic resonance imaging, any joint of lower extremity, without contrast, followed by with contrast |
Not Covered CPT Codes
| Code | Type | Description | Reason |
|---|---|---|---|
| 70554 | CPT | Magnetic resonance imaging, brain, functional MRI; including test selection and administration of neurofunctional testing | Not covered for indications listed in CPB 0171 |
| 70555 | CPT | Magnetic resonance imaging, brain, functional MRI; requiring physician or psychologist administration of entire neurofunctional testing | Not covered for indications listed in CPB 0171 |
HCPCS Codes
| Code | Type | Description |
|---|---|---|
| L3030 | HCPCS | Foot, insert, removable, formed to patient foot, each |
| L3050 | HCPCS | Foot, arch support, removable, premolded, metatarsal, each |
Key ICD-10-CM Diagnosis Codes
| Code | Description |
|---|---|
| C49.20 | Malignant neoplasm of connective tissue of lower limb, including hip, unspecified |
| C49.21 | Malignant neoplasm of connective tissue of right lower limb, including hip |
| C49.22 | Malignant neoplasm of connective tissue of left lower limb, including hip |
| C76.50 | Malignant neoplasm of lower limb, unspecified |
| C76.51 | Malignant neoplasm of right lower limb |
| C76.52 | Malignant neoplasm of left lower limb |
| D21.20 | Benign neoplasm of connective and other soft tissue of lower limb, unspecified |
| D21.21 | Benign neoplasm of connective and other soft tissue of right lower limb |
| D21.22 | Benign neoplasm of connective and other soft tissue of left lower limb |
| D48.0 | Neoplasm of uncertain behavior of bone and articular cartilage |
| G57.60 | Lesion of plantar nerve, unspecified lower limb |
| G57.61 | Lesion of plantar nerve, right lower limb |
| G57.62 | Lesion of plantar nerve, left lower limb |
| G57.63 | Lesion of plantar nerve, bilateral lower limbs |
| G71.0 | Duchenne or Becker muscular dystrophy |
| G71.1 | Emery-Dreifuss muscular dystrophy |
| G71.2 | Congenital muscular dystrophy |
| G71.3 | Mitochondrial myopathy |
| G71.4 | Inflammatory and immune myopathies |
| G71.5 | Other specified myopathies |
| G71.6 | Metabolic myopathies |
| G71.7 | Primary disorders of muscle in diseases classified elsewhere |
| G71.8 | Other specified primary disorders of muscles |
| G71.9 | Primary disorder of muscle, unspecified |
| I69.831 | Monoplegia of upper limb following other cerebrovascular disease affecting right dominant side |
| I69.832 | Monoplegia of upper limb following other cerebrovascular disease affecting left dominant side |
| I69.833 | Monoplegia of upper limb following other cerebrovascular disease affecting right non-dominant side |
| I69.834 | Monoplegia of upper limb following other cerebrovascular disease affecting left non-dominant side |
| I69.835 | Monoplegia of upper limb following other cerebrovascular disease affecting unspecified side |
The full policy includes 267 ICD-10-CM codes. Review the complete code set at CPB 0171 on PayerPolicy.
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